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Updated: Jun 17, 2026

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
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结合MTHFR多形态与白内障风险在患者中与初级中枢神经系统淋巴瘤治疗以甲索基疗法治疗的患者中

Philipp Karschnia1, Sylvia C Kurz2, Priscilla K Brastianos2

  • 1From the Division of Neuro-Oncology (P.K., P.K.B., S.F.W., A.G., S.J., M.P., N.N., S.R.P., J.D.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurosurgery (P.K., J.-C.T.), Ludwig-Maximilians-University Munich; German Cancer Consortium (DKTK) (P.K.), Partner Site Munich; Section for Neuro-Oncology (S.C.K.), Department of Neurology, University of Tuebingen, Germany; and Department of Neurology (T.T.B.), Brigham and Woman's Hospital, Harvard Medical School, Boston, MA. p.karschnia@med.uni-muenchen.de.

Neurology
|August 1, 2023
PubMed
概括

MTHFR 1298A→C基因型与接受高剂量甲状腺激素治疗的中枢神经系统原发性淋巴瘤患者的白细胞脑病变风险较高有关. 这一遗传因素可能会降低整体存活率,突出其在治疗管理中的重要性.

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