出生时的大小预测了以后的大脑容量
Samson Nivins1, Eleanor Kennedy1, Christopher McKinlay1,2
1Liggins Institute, University of Auckland, Building 503, Level 2, 85 Park Road, Auckland, New Zealand.
Scientific reports
|August 1, 2023
概括
生命早期的成长和出生时间会影响儿童中期的大脑发育. 出生时头部周长较小,强烈预测大脑体积较小,即使是在早产晚期或满期出生的儿童中.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 医疗成像医学成像
背景情况:
- 孕期,出生体重和头周长等围产期因素对早期大脑发育至关重要.
- 这些因素对婴儿中期大脑结构的长期影响,对于晚期早产和早产婴儿的长期影响尚未完全理解.
研究的目的:
- 为了研究9-10岁时怀孕,出生体重,头周和大脑体积和白质微观结构之间的关联.
- 确定儿童中期大脑发育的关键围产预测因子,用于晚期早产和满期出生的儿童.
主要方法:
- 脑磁共振成像 (MRI) 对来自CHYLD研究队列的111名儿童 (年龄为9-10岁) 进行.
- 使用FreeSurfer进行体积大脑分析,并使用基于导管的空间统计 (TBSS) 对扩散MRI数据进行白质微结构评估.
主要成果:
- 较短的怀孕期,较低的出生体重和较小的头周长与9-10岁的全球和区域大脑体积减少有关.
- 出生的头周长是以后大脑体积的最重要的预测因素.
- 虽然孕期和绝对出生体重与白质扩散指标没有关联,但出生体重较低的z-score与分数异位变异性增加和辐射扩散性降低相关.
结论:
- 产前生长和出生时间仍然与童年中期的大脑发育有关,即使对于晚期或满期出生的婴儿也是如此.
- 出生时的头周长是随后大脑体积的关键指标.
- 出生体重z-score可能反映出白质发育的微妙差异.
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