皮质微结构变化预测了老年人粉样蛋白藏的tau积累和情节性记忆衰退
Geoffroy Gagliardi1,2,3, Elena Rodriguez-Vieitez1,2,4, Victor Montal5,6
1Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Communications medicine
|August 1, 2023
概括
在认知正常的个体中,高皮层平均扩散度 (cMD) 与粉样蛋白病理结合,预测未来的积和记忆力下降,特别是在脑内皮层. 这表明cMD可能是阿尔茨海默病早期生物标志物.
科学领域:
- 神经成像是一种神经成像.
- 神经退行性疾病 神经退行性疾病
- 认知老龄化 认知老龄化
背景情况:
- 非侵入性扩散权重成像 (DWI) 测量皮质平均扩散度 (cMD),这是早期神经元损伤的潜在标志物.
- 在认知正常的老年人中,cMD与tau交叉相关.
- 这项研究调查了cMD与粉样蛋白病理学患者的纵向积和记忆衰退的关系.
研究的目的:
- 为了确定基线粉样蛋白状况和cMD是否相互作用来预测纵向积.
- 评估基线粉样蛋白状况和cMD是否相互作用,以预测纵向情节性记忆衰退.
- 为了识别阿尔茨海默病 (AD) 进展的早期标志物.
主要方法:
- 包括来自哈佛老化大脑研究的122名认知正常参与者.
- 数据包括DWI,T1w-MRI,粉样蛋白和tau PET以及逻辑记忆延迟回忆 (LMDR).
- 线性混合效应模型分析了粉样状况和cMD与纵向和LMDR的相互作用.
主要成果:
- 粉样蛋白状况和基线cMD之间的显著相互作用预测了在内皮层的纵向积.
- 较大的基线cMD预测了粉样蛋白阳性个体的内腔积.
- 一个显著的相互作用预测了纵向LMDR下降,与基线输入性cMD预测了粉样蛋白阳性个体的记忆力下降.
结论:
- 氨基粉症和升高的内腔cMD的组合确定了积的风险.
- 这种组合预测了短期的,与阿尔茨海默病相关的情节性记忆衰退.
- 结果表明cMD是早期AD临床试验的有价值的生物标志物.
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