在适应性种群的长距离联系效应
1Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint-Petersburg, Russia, 194223. igor.rouzine@iephb.ru.
Scientific reports
|August 1, 2023
概括
在性种群中,在基因组中相距很远的基因不会独立进化. 由于克隆干扰和遗传背景影响,链接效应持续存在,影响着等位基因动态.
科学领域:
- 进化遗传学的进化遗传学
- 人口遗传学 人口遗传学
- 基因组学就是基因组学.
背景情况:
- 靠近基因组的基因因因链接而具有共同的进化命运.
- 人们认为,重组使得遥远的基因能够独立进化.
- 以前的模型专注于突变驱动的进化,而不是先前存在的变异.
研究的目的:
- 调查长基因组中的遥远基因是否在依赖于先前存在的遗传变异时独立进化.
- 探索超越简单的近距离或重组率的链接效应的影响.
主要方法:
- 使用蒙特卡洛算法模拟了一个具有多个位点和固定的选择系数的单 haploid 种群模型.
- 模拟集中在具有小初始频率的有益等位基因的动态.
- 分析检查了链接效应,等位基灭绝和跨位置的替代率.
主要成果:
- 即使在遥远的位置上也观察到显著的链接效应,不随着距离或再组合而减少.
- 克隆干扰导致了有利的等位基因在很大一部分位置的灭绝.
- 遗传背景影响导致替代率的广泛变化,一些位点的演变速度远比单位模型预测的要快得多.
结论:
- 性种群中遥远的基因组区域不会作为独立的单元进化.
- 联系和背景效应破坏了独立的进化,这对理解基因组进化有影响.
- 这些发现可能会提供有关SARS-CoV-2变种等病原体快速演变的见解.
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