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Updated: Jul 20, 2025

Cycloheximide Chase Analysis of Protein Degradation in Saccharomyces cerevisiae
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在ER相关蛋白质降解过程中基质加工的机制

John C Christianson1, Ernst Jarosch2, Thomas Sommer3,4

  • 1Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. john.christianson@ndorms.ox.ac.uk.

Nature reviews. Molecular cell biology
|August 1, 2023
PubMed
概括

维持蛋白质完整性对于生物的生存至关重要. 细胞内膜网关联蛋白质降解 (ERAD) 使用膜结合的机械来通过ubiquitin-proteasome系统消除错误折叠的蛋白质.

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