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Updated: Jul 20, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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通过DNA甲基化失调调节SETD2损失在瘤发生中的作用

Hira Javaid1, Alessandro Barberis2, Olga Chervova3

  • 1Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK.

BMC cancer
|August 1, 2023
PubMed
概括

失去SETD2,一个调节H3K36me3的酶,在大多数癌症中破坏了DNA甲基化. 这种DNA甲基化失调会影响基因表达和癌症的攻击性,这表明SETD2在瘤发生过程中的新角色.

关键词:
通过DNA甲基化.H3K36me3是什么意思 H3K36me3是什么意思机器学习生物标志物癌生物标志物是癌的生物标志物.这就是SETD2的原因.

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