在细胞免疫治疗中MSCs和CAR-MSCs的作用
Lun Yan1, Jing Li1, Cheng Zhang2
1Medical Center of Hematology, State Key Laboratory of Trauma, Burn and Combined Injury, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Cell communication and signaling : CCS
|August 1, 2023
概括
介质细胞干细胞 (MSCs) 提供了一种新的解决方案,以增强仿真抗原受体 (CAR) 细胞疗法. CAR-MSCs可以克服像持久性差和低效率这样的局限性,改善癌症免疫治疗结果.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞疗法细胞疗法
- 在瘤学瘤学.
背景情况:
- 化学抗原受体 (CAR) 细胞疗法,包括CAR-T细胞,在免疫治疗中至关重要,但面临诸如细胞持久性差,功能障碍,疾病复发和对固体瘤有效性有限等挑战.
- 介质细胞干细胞 (MSC) 以其免疫调节特性和增强抗癌功能的潜力而闻名.
- 目前基于CAR的疗法与瘤微环境抑制和与免疫相关的毒性作斗争.
研究的目的:
- 审查介质干细胞 (MSC) 作为化学抗原受体 (CAR) 工程的生物载体的潜力.
- 探索MSC如何克服与当前基于CAR的细胞免疫疗法相关的局限性.
- 讨论MSC及其外体在调节瘤微环境和增强CAR产品疗效方面的作用.
主要方法:
- 对MSC特征,免疫调节功能及其在CAR治疗中的应用现有文献的审查.
- 分析MSC衍生的外体和它们的治疗潜力.
- 检查MSC与CAR相关产品和CAR修改的MSC (CAR-MSC) 的整合.
主要成果:
- MSCs具有显著的免疫调节功能,可以利用这些功能来改善CAR细胞治疗.
- 来自MSC的外体具有治疗潜力,可以调节免疫反应.
- CAR-MSCs证明了克服细胞免疫疗法的关键挑战的能力,包括持久性和有效性.
结论:
- 介酶干细胞 (MSCs) 是开发基于CAR的先进疗法的一个有前途的平台.
- 使用MSC作为CAR的载体可以提高治疗疗效,持续性和安全性.
- 对CAR-MSCs和MSC衍生的外体的进一步研究是有必要的,以优化癌症免疫治疗策略.
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