在2021年批准的新药的合成方法
Emma L McInturff1, Scott P France2, Carolyn A Leverett1
1Groton Laboratories, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, Connecticut 06340, United States.
Journal of medicinal chemistry
|August 1, 2023
概括
本综述涵盖了2021年批准的35个新化学实体 (NCE) 的顶级工艺规模合成策略. 它强调了未来药物设计的潜在线索,以及对分子识别的洞察力.
科学领域:
- 药用化学 医学化学
- 过程化学 过程化学
- 药物发现 药物发现 药物发现
背景情况:
- 持续开发新的药物,针对疾病中的生物机制.
- 新化学实体 (NCE) 提供了对分子相互作用的洞察力.
- 小分子和抗体-药物联合体是关键的治疗方式.
研究的目的:
- 审查2021年全球批准的35个NCE的最可能的大规模合成路线.
- 为最近批准的药物的合成提供见解.
- 为了确定新的候选药物过程化学的趋势.
主要方法:
- 对2021年批准的35个NCE的合成路线的分析.
- 专注于工艺规模制造方面的考虑.
- 根据已公布的数据,确定可能的合成方法.
主要成果:
- 对35个不同的NCE进行了合成路径的详细检查.
- 突出了高效和可扩展的合成方法.
- 讨论药物合成中的挑战和创新.
结论:
- 2021年NCE的合成涉及多样化和复杂的化学策略.
- 了解这些合成方法有助于未来的药物开发.
- 过程化学在为患者提供新药方面发挥着至关重要的作用.
相关概念视频
Synthetic Biology
4.8K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Golden rice
Golden rice is a genetically modified...
4.8K
Drug Discovery: Overview
8.1K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
8.1K
Structure-Activity Relationships and Drug Design
770
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
770
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
148
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
148
Prescription, Nonprescription and Orphan Drugs
765
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
765
Drug Nomenclature
1.8K
During the development of a new pharmaceutical, the manufacturer initially assigns a code name to the drug. Once approved, the drug receives a United States Adopted Name (USAN)—a generic, nonproprietary designation. Upon being listed in the United States Pharmacopeia, this nonproprietary name becomes the drug's official name. Additionally, the manufacturer assigns a proprietary name or trademark, which serves as the brand name under which the drug is marketed. It is worth noting that...
1.8K


