糖尿病大鼠的光生物调节:对形态,胰腺参数和葡萄糖平衡的影响
Isabella Liba Pandolfo1, Mirian Bonifacio1, Izabelle Dias Benfato1
1Department of Biosciences, Institute of Health and Society, Federal University of São Paulo (UNIFESP), Santos, Brazil.
Journal of biophotonics
|August 2, 2023
概括
光生物调节疗法在治疗糖尿病方面表现有前途. 这项研究发现,PBM减少了糖尿病大鼠的体重减轻和改善胰腺健康.
科学领域:
- 生物医学工程 生物医学工程
- 内分泌学 在内分泌学.
- 照相医疗 (photomedicine) 是一种医学技术.
背景情况:
- 光生物调制 (PBM) 在伤口愈合,糖尿病微血管病和视网膜病的治疗效益是公认的.
- 对于管理糖尿病 (DM) 的PBM的应用仍然在很大程度上未被探索.
- 鉴于它已知的对细胞过程的影响,研究PBM在糖尿病治疗中的潜力至关重要.
研究的目的:
- 评估PBM对胰腺形态学的影响.
- 在糖尿病的实验模型中评估PBM对胰岛素和葡萄糖耐受性的影响.
- 为了确定PBM是否可以减轻糖尿病诱导的不良影响.
主要方法:
- 在大鼠中诱导糖尿病 (DM),使用60毫克/公斤剂量的链毒素 (STZ).
- 随后,老鼠使用808nm波长的30J/cm2.2,用PBM治疗它们.
- 在安乐死后分析了胰腺形态参数,胰岛素免疫活性和8-基-2'-脱氧氨酸 (8-OHdG) 水平.
主要成果:
- 与对照组相比,PBM治疗导致STZ诱导的糖尿病大鼠体重减轻.
- 用PBM治疗的动物表现出更高的体重值.
- 在接受PBM治疗的组中观察到胰腺β细胞数量的显著增加.
结论:
- 光生物调节疗法在糖尿病的老鼠模型中显示出对减肥的保护作用.
- PBM对胰腺表现出刺激作用,特别是在β细胞群中.
- 这些发现凸显了PBM在管理与糖尿病相关的临床条件方面的有希望的治疗潜力.
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