在下膜通道和下形状的形态整合
Daniah M Alhazmi1,2, Christina L Nicholas3,4, Siddharth R Vora5
1Department of Oral Pathology, Radiology, and Medicine, University of Iowa, College of Dentistry, Iowa City, Iowa, USA.
Orthodontics & craniofacial research
|August 2, 2023
概括
下膜神经和下有着强烈的整合,这表明神经在发育过程中影响下形状. 这一发现可能解释了面显微症中的下缺陷.
科学领域:
- 牙科的解剖学 牙科的解剖学
- 发育生物学是发展生物学.
- 生物医学成像学 生物医学成像学
背景情况:
- 下膜 (IA) 神经和下同时发育.
- 像面显微症 (CFM) 这样的先天性异常表明受影响的一侧没有IA通道.
- 假设IA神经和下形状之间的潜在形态融合.
研究的目的:
- 为了研究IA通道 (作为IA神经的代理) 和下形状之间的形态整合.
- 分析这些结构在不同骨类 (I,II和III) 的形状变化.
主要方法:
- 利用80个形束计算断层扫描 (CBCT) 对16-56岁的个体进行扫描.
- 应用几何形态分析来评估IA通道和下形状之间的整合.
- 采用Procrustes ANOVA来评估骨I,II和III类受试者之间的形状变化.
主要成果:
- 在IA通道和下的后/下边界之间表现出强烈的形态融合 (r-PLS = .845,P = .001).
- 确认IA通道和下整体形状之间的显著整合 (r-PLS = .866,P = .001).
- 在骨I和II类 (P = .008) 和II和III类 (P = .001) 之间确定了下形状的统计学上显著的变化.
结论:
- 这些发现表明,IA神经在早期发育期间塑造下的过程中起着重要作用.
- 这种整合可能是下缺陷的关键因素,在面显微症中观察到.
- 需要进一步的研究来探索这种发育关系的含义.
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