拓调节比斯穆特纳米半导体用于免疫细胞死亡介导的超热治疗
Guobo Chen1, Zhijin Yang2, Jun Du1
1School of Materials and Chemistry, Institute of Bismuth, Shanghai Collaborative Innovation Center of Energy Therapy for Tumors, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Small (Weinheim an der Bergstrasse, Germany)
|August 2, 2023
概括
这项研究引入了一种双响应策略,使用硫化氧化物纳米粒子来精确控制免疫细胞死亡 (ICD),通过超声波和光激活增强瘤免疫治疗.
科学领域:
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
- 免疫学 免疫学 免疫学
背景情况:
- 免疫细胞死亡 (ICD) 对于通过死细胞抗原激活抗瘤免疫是至关重要的.
- 目前用于ICD的小分子药物缺乏精确的控制,限制了治疗疗效.
- 开发可控制的ICD诱导方法对于改善癌症免疫疗法至关重要.
研究的目的:
- 为瘤治疗和ICD激活提出声光双响应策略.
- 为增强ICD诱导构建可控制的基于木的纳米半导体.
- 研究一种新型复合材料和双重刺激对瘤治疗和免疫反应的协同效应.
主要方法:
- 使用BiF3作为模板的硫 bismuth氧化物 (Bi2O3-xSx) 纳米粒子 (BS) 的拓合成.
- 使用超声波来诱导通过BS的反应性氧物种 (ROS) 生产和声催化.
- 在光下将BS的光热转化与ROS生成和ivermectin (IVM) 结合起来,形成用于协同治疗的BSM复合物.
主要成果:
- BS纳米颗粒显示出声催化活性,产生ROS和消耗谷来诱导ICD.
- 硫可以在光下进行光热转换,从而改善瘤治疗.
- 由声波/光激活的BSM复合物显著促进了ICD和树突细胞 (DC) 的成熟.
结论:
- 拟议的声光双响应策略有效诱导ICD并增强瘤治疗.
- BSM复合剂为可控制的ICD诱导和协同的癌症免疫疗法提供了一个有前途的方法.
- 这一策略为改善癌症治疗治疗结果提供了一条可行的途径.
更多相关视频
09:01Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
3.2K
06:45In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System
Published on: July 2, 2020
4.4K
相关概念视频
01:27Cytotoxic T Cells-mediated Immune Response
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.