生下双胞胎:对非常早产婴儿长期神经发育的影响 - 一项队列研究
Camilla Fontana1, Paola Schiavolin1, Giulia Ardemani2
1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, NICU, Milan, Italy.
Frontiers in pediatrics
|August 2, 2023
概括
与学龄前单生婴儿相比,出生非常早的双胞胎婴儿没有增加神经发育障碍的风险. 在对伴随疾病进行调整后的5年内,单胆双胞胎在特定领域的得分较低.
科学领域:
- 新生儿医学 新生儿医学
- 发育儿科 发育儿科
- 围产期流行病学 围产期流行病学
背景情况:
- 过早分娩 (<32周怀孕) 和出生体重非常低 (<1,500克) 对长期神经发育结果构成风险.
- 双胞胎怀孕与早产和不良周产期结果的风险增加有关.
研究的目的:
- 研究双胞胎出生对非常早产婴儿神经发育结果的影响.
- 为了比较双胞胎与单身双胞胎的神经发育轨迹,直到5岁.
主要方法:
- 301名意大利早产婴儿 (妊娠年龄 ≤32周,出生体重 <1,500克) 的回顾性队列研究.
- 使用格里菲斯精神发展尺度修订 (GMDS-R) 的神经发育评估,在2岁时进行了校正,并在5岁时进行了时间表.
- 使用线性混合效应模型进行统计分析,对妊娠年龄进行调整,对妊娠年龄状态小,性别,NICU停留,社会经济地位和并发症得分进行调整.
主要成果:
- 双胞胎和单生子在2岁或5岁之间GMDS-R平均得分没有显著差异.
- 经过对并发症评分进行调整后,单胆双胞胎在5岁时在听力,语言和表现子表格上表现出较低的分数.
- 在比较单双胞胎和单双胞胎时,胆性没有显著影响结果.
结论:
- 总的来说,生得非常早的双胞胎婴儿在学前年龄时与单生婴儿相比,不会面临更高的神经发育障碍的风险.
- 单双胞胎的特定神经发育缺陷可能会在5岁时出现,特别是在考虑到健康并发症后.
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