基于大样本CT数据的中国儿童结构参数的正常参考值和估计公式
Yong Qin1, En Liu2, Xiaoying Ni1
1Department of Radiology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in pediatrics
|August 2, 2023
概括
本研究使用CT数据确定了中国儿童脏结构参数 (RSP) 的正常参考值和估计公式. 这些发现有助于评估儿科患者的发育和疾病.
科学领域:
- 儿科放射学 儿科放射学
- 医疗成像医学成像
- 脏生理学 脏生理学
背景情况:
- 准确评估儿童的发育和疾病对于有效的临床管理至关重要.
- 在儿科患者群体中确定结构参数 (RSP) 的规范性数据对于准确的诊断至关重要.
- 现有的RSP参考值可能不适用于所有人,需要特定人群的数据.
研究的目的:
- 在一大批中国儿童中确定各种脏结构参数 (RSP) 的正常参考值.
- 根据随时可用的临床数据 (年龄,身高,体重) 开发RSP的估计公式.
- 为临床评估中国儿童发育和疾病提供有价值的数据资源.
主要方法:
- 利用了0-17岁的438名中国儿童的计算机断层扫描 (CT) 数据,脏成像正常.
- 测量双边RSP,包括脏的长度,宽度,厚度,体积,皮层厚度和动脉直径.
- 采用了统计分析,包括皮尔森相关性,肯德尔等级相关性,配对t测试和多重线性回归.
主要成果:
- 脏结构参数 (RSP) 通常随着年龄的增长而增加,而身高显示出最强的相关性.
- 在RSP和性别之间没有发现显著的相关性.
- 建立了RSP的估计公式,证明了与年龄,身高和体重的显著线性关系.
结论:
- 本研究为中国儿童的RSP提供了首个基于CT的大样本参考值和估计公式.
- 开发的公式和参考范围为评估儿科患者脏生长和疾病提供了关键数据.
- 这些发现有助于提高儿科脏病和放射学诊断准确度和临床决策.
相关概念视频
Serum Studies: Renal Function Tests
23
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
23
Renal Clearance
1.1K
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
1.1K
Factors Affecting Renal Clearance: Renal Impairment
119
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
119
Determination of Renal Drug Clearance: Graphical and Midpoint Methods
156
Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
156
External Anatomy of the Kidney
1.2K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
1.2K


