相关实验视频

Updated: Jul 20, 2025

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

第一季度血清上的非向代谢因子意味着与BMI相关的代谢干扰在高血压疾病的发展中:一项发现性研究

Yuanyuan Li¹, Ke Pan², Susan L McRitchie¹

¹Department of Nutrition, Nutrition Research Institute, University of North Carolina at Chapel Hill School of Public Health, Chapel Hill, NC, United States.

Frontiers in nutrition

|August 2, 2023

概括

怀孕早期的高体重指数 (BMI) 与妊娠高血压障碍 (HDP) 有关. 代谢分析显示维生素D3,氨酸和氨酸代谢发生了变化,这表明了干预的目标.

科学领域:

产科和妇科产科和妇科
代谢学代谢学代谢学
营养科学营养科学

背景情况:

怀孕早期的体重指数 (BMI) 是妊娠高血压疾病 (HDP) 的重要危险因素.
连接BMI和HDP的精确生物机制仍然不完全理解.
研究与BMI相关的代谢概况可以阐明HDP的病原性.

研究的目的:

调查第一季度BMI与孕妇代谢干扰之间的关系.
根据他们的BMI来确定在患有HDP的女性中发生变化的特定代谢途径.
探索潜在的代谢标,以减轻HDP风险.

主要方法:

来自154名孕妇的血清样本 (105名没有HDP,49名有HDP) 用超高性能液态染色学高分辨率质谱法 (UHPLC HR-MS) 进行分析.
多变量回归模型确定了与BMI和HDP相关的代谢物和途径.
代谢物识别利用了内部标准库和公共数据库;使用Mummichog算法进行了途径分析.

主要成果:

维生素D3和素代谢与HDP和非HDP组的BMI有关.
在所有BMI类别中开发HDP的女性中,托芬代谢得到了丰富.
患有HDP的孕妇表现出更大的与BMI相关的代谢变化,基于BMI (正常体重:炎症/免疫;超重/肥胖:代谢综合征,氧化应激) 的明显途径丰富.

结论:

第一季度BMI升高表明潜在的代谢综合征有助于HDP.
改变的维生素D3和酸盐代谢是营养干预的潜在目标.
针对这些代谢途径可能有助于减少炎症和减轻HDP发病.

关键词:

第一个季度的第一季度.这就是为什么BMI是BMI.在怀孕期间的高血压疾病.代谢干扰代谢干扰没有目标的代谢学.

更多相关视频

Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry UPLC-HRMS

Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry UPLC-HRMS

Published on: May 20, 2013

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure

Published on: June 25, 2010

相关概念视频

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...