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有氧运动训练对小鼠肠道微生物群在帕金森病中的影响
Tianlun Fan1, Xiating Li2, Xiang Zhang2
1Department of Rehabilitation Medicine, the First Affiliated Hospital of Hainan Medical College, Hainan, China.
Turkish journal of biology = Turk biyoloji dergisi
|August 2, 2023
概括
有氧运动训练 (AET) 通过改变细菌丰富度,在帕金森病 (PD) 的小鼠中部分改善了肠道微生物群. AET没有显著改变物种丰富性或多样性,但在PD小鼠中调节了特定的细菌群.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 运动科学 运动科学
背景情况:
- 肠道微生物失调是帕金森病 (PD) 的潜在危险因素.
- 运动通常有利于肠道微生物群的组成.
- 在PD中,有氧运动训练 (AET) 对肠道微生物群的影响尚不清楚.
研究的目的:
- 在PD的小鼠模型中研究AET对肠道微生物环境的影响.
- 在PD小鼠中识别受AET影响的特定细菌种群.
主要方法:
- 16S rRNA基因测序是在假操作小鼠,PD小鼠和接受AET的PD小鼠的便样本上进行的.
- 进行了对细菌物种丰富度,多样性和相对丰富性的比较分析.
主要成果:
- 在PD小鼠中,AET没有显著改变物种丰富性或细菌多样性.
- 与虚假小鼠相比,PD小鼠显示出几个细菌类和属的丰度变化.
- 在PD小鼠中,AET部分逆转了这些变化,并增加了PD小鼠中的*Lactobacillus gasseri*等有益细菌.
结论:
- AET可以调节PD小鼠的肠道微生物群组成,部分地挽救失生变化.
- 在接受AET治疗的小鼠中,特定的细菌种群,包括*Lactobacillales*和*Lactococcus*,被确定为具有歧视性的.
- 在帕金森病中,AET显示了改善肠道微生物环境的潜力.
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