响应pH的可脱的聚合物纳米粒子作为光动力学药物载体:合成,表征和体外研究
1Division of General Education, Seokyeong University, Republic of Korea.
Turkish journal of biology = Turk biyoloji dergisi
|August 2, 2023
概括
响应pH的纳米颗粒将治疗剂传递到特定的部位. 这些对酸敏感的纳米载体在酸性瘤环境中释放光敏剂,增强光动力学治疗的疗效.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 两性块共聚合物形成可脱的纳米颗粒,用于向药物输送.
- 治疗剂的特定部位输送仍然是医学上的一个挑战.
研究的目的:
- 为了合成和表征pH响应的可散射纳米粒子,用于有针对性的传递光敏剂.
- 为了评估纳米粒子的稳定性,药物释放动力学和癌细胞中的疗效.
主要方法:
- 环开聚合合成聚乙烯糖醇-b-聚乙烯-基-L-氨酸 (PEG-PBLG) 共聚物.
- 纳米颗粒的形成,原波林IX (PpIX) 的封装和pH依赖的分解研究.
- 在SCC7癌细胞的体外细胞毒性和细胞吸收研究中.
主要成果:
- PEG-PBLG纳米颗粒在pH 7.4时表现出稳定性,在pH 5.0时表现出快速分解.
- 载有PpIX的纳米粒子在酸性条件下显示pH触发释放和光恢复.
- 这些纳米颗粒在辐射后增强了癌细胞中的光毒性,并在癌细胞内体中降解.
结论:
- 响应pH的可散射纳米粒子是PpIX等光动力学剂的有效载体.
- 这些纳米粒子在酸性瘤微环境中促进特定部位的药物释放.
- 开发的纳米载体系统显示了改善光动力学治疗结果的前景.
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