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在临床上健康的狗中,用于磁共振脑成像的单片3D双反转恢复

Miseong Je¹, Sunho Yang¹, Dongjae Lee¹

¹College of Veterinary Medicine and the Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea.

Frontiers in veterinary science

|August 2, 2023

概括

这项研究表明,3D双反转恢复 (DIR) 磁共振成像 (MRI) 序列可以改善狗大脑中的灰色和白色物质可视化. 这些序列减少了文物,为诊断狗的脑疾病提供了基础.

科学领域:

兽医辐射学兽医辐射学
神经成像是一种神经成像.
比较医学是一种比较医学.

背景情况:

磁共振成像 (MRI) 对于兽医大脑诊断至关重要.
传统的MRI序列可以产生像部分体积平均值这样的文物,阻碍了详细的组织分析.
双反转恢复 (DIR) 序列在人类神经成像中显示出对人工物减少的希望.

研究的目的:

在正常的狗大脑中评估单片3D DIR序列的磁共振特征.
评估DIR序列在改善灰色和白色物质分化和减少狗的图像工件方面的有效性.

主要方法:

在五只健康的比格尔犬中获取自旋回声T2加权 (T2W),FLAIR以及灰质 (GM) 和白质 (WM) 选择性单片3D DIR序列.
灰白质区分和图像工件的定性评估.
对GM,WM和脑脊液 (CSF) 的对比比率 (CRs),信号噪声比率 (SNRs) 和对比噪声比率 (CNRs) 的定量分析.

主要成果:

在整体灰白物质界限划分方面,GM选择性3D DIR优于T2W和FLAIR.
WM选择性3D DIR在长髓中改善了灰白物质的区分,T2W和FLAIR显示了文物.
3D DIR 序列通常显示出更少的文物,并在重建的图像中保持空间分辨率.

结论:

单片3D DIR序列有效地抑制不需要的信号,增强狗大脑灰质和白质之间的对比度.
这些发现支持使用3D DIR序列作为狗神经成像的有价值工具.
这项研究为未来对DIR序列的研究提供了基础,用于评估犬类大脑病理.

关键词:

大脑大脑大脑的大脑大脑狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗双重逆转恢复恢复的方法灰色物质是一种灰色物质.磁共振成像技术的使用白质是白色物质的组成部分.

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