在性结肠炎中分析与cuproptosis相关的基因和基于机器学习的免疫特征
Zhengyan Wang1, Ying Wang2, Jing Yan1
1Changchun University of Chinese Medicine, Changchun, China.
Frontiers in medicine
|August 2, 2023
概括
与cuproptosis相关的基因 (CRG) 与性结肠炎 (UC) 的发展有关. 一个新的5基因XGB模型准确地预测UC亚型,有助于理解这种炎症性肠病.
科学领域:
- 细胞死亡机制 细胞死亡机制
- 线粒体代谢的代谢过程
- 炎症性疾病是一种炎症性疾病.
背景情况:
- 型亡是一种新的细胞死亡途径,涉及蛋白质化和线粒体功能.
- 性结肠炎 (UC) 是一种慢性炎症性肠病,其全球发病率正在增加.
- 与cuproptosis相关的基因 (CRG) 与各种癌症有关,但它们在UC中的作用尚不清楚.
研究的目的:
- 调查CRG在UC病变发生中的作用.
- 根据CRG表达式来识别UC亚型.
- 使用机器学习开发UC的预测模型.
主要方法:
- 在UC样本中进行差异基因表达分析和CRG分析.
- 免疫细胞透分析和权重基因联合表达网络分析 (WGCNA).
- 机器学习模型 (XGB,SVM,RF,GLM) 的开发和验证,包括外部数据集.
主要成果:
- 13个CRG在UC中显著差异地表达.
- 根据CRG配置文件确定了两个UC亚型,具有明显的免疫细胞透.
- 一个5基因XGB模型在预测UC亚型方面表现出高准确性 (AUC=0.981),得到了外部验证.
结论:
- CRG在UC的发展和进步中发挥着重要作用.
- 基于CRG的亚型化提供了关于UC异质性和免疫反应的见解.
- 开发的XGB模型为预测UC亚型提供了可靠的工具.
相关概念视频
Inflammatory Bowel Disease I: Ulcerative Colitis
215
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
215
Drugs for Treatment of Ulcerative Colitis in IBD
175
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
175
Inflammatory Bowel Disease II: Crohn's Disease
293
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
293


