通过单碳代谢调节DNA甲基化:健康衰老的一个里程碑
Sang-Woon Choi1,2, Simonetta Friso3
1Chaum Life Center, CHA University School of Medicine, Seoul 06062, Korea.
Nutrition research and practice
|August 2, 2023
概括
营养通过影响关键的生物过程和表观遗传调节,影响健康的衰老. 参与单碳代谢的特定营养素可以修改与年龄相关的DNA甲基化,可能减轻与年龄相关的疾病.
科学领域:
- 老年学和营养科学研究
- 表观遗传学和衰老研究研究.
背景情况:
- 健康衰老的特点是延长寿命和健康寿命.
- 营养显著影响衰老的特征,如氧化应激,线粒体功能和免疫反应.
- 表观遗传调节,特别是DNA甲基化,是衰老过程中的关键因素.
研究的目的:
- 探索营养在健康衰老中的作用.
- 研究营养素,特别是单碳代谢中的营养素如何影响与年龄相关的DNA甲基化.
- 了解营养干预措施在缓解与年龄有关的疾病方面的潜力.
主要方法:
- 评论关于营养,衰老和表观遗传学的科学文献.
- 分析单碳代谢在DNA甲基化中的作用.
- 检查特定的营养素 (B族维生素,氨酸,胆,贝他因,血清素) 以及它们对表观遗传修饰的影响.
主要成果:
- 营养素和生物活性食品成分对衰老的特征有有益影响.
- 一个碳代谢,涉及B族维生素和甲基供体,调节S-adenosylmethionine和S-adenosylhomocysteine平衡.
- 与年龄相关的DNA甲基化可以通过单碳营养素来调节.
结论:
- 营养是促进健康衰老和影响表观遗传调节的关键因素.
- 通过单碳营养素调节与年龄相关的DNA甲基化可能会改变与年龄相关的生理和病理过程.
- 虽然衰老是不可避免的,但针对DNA甲基化的营养策略可以帮助缓解与年龄相关的疾病.
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