在激素敏感乳腺癌中PGRMC1的临床重要性
Xiangyan Ruan1,2, Alfred O Mueck1,2
1Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Breast care (Basel, Switzerland)
|August 2, 2023
概括
孕激素受体膜成分1 (PGRMC1) 显示出作为激素依赖性乳腺癌 (BC) 风险和预后的预测标记物的潜力. 瘤中的PGRMC1表达与较差的存活率相关,可以在血液中检测到,优于其他瘤标志物.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 生物标志物发现发现
背景情况:
- 孕激素受体膜成分1 (PGRMC1) 是膜相关孕激素受体蛋白 (MAPR) 家族中的多功能受体.
- 目前正在研究PGRMC1作为激素依赖性乳腺癌 (BC) 风险的潜在预测标志物.
- 一个系统的研究计划涉及细胞,动物和临床研究已经进行.
研究的目的:
- 评估PGRMC1作为激素依赖性乳腺癌风险增加的预测标志物.
- 评估PGRMC1在预测乳腺癌患者预后方面的作用.
- 总结PGRMC1在BC预后和HRT相关风险中的双重功能.
主要方法:
- 使用BC细胞和合成孕激素进行体外研究.
- 动物异种移植研究以评估瘤扩散.
- 在BC患者的临床研究,包括PGRMC1表达与瘤特征和血液水平的相关性,以及正在进行的激素替代疗法 (HRT) 研究.
主要成果:
- 合成孕激素,但不包括孕激素,诱导了剂量和时间依赖的BC细胞增殖,主要是在存在PGRMC1.
- 合成孕激素在动物模型中增加了雌醇诱导的瘤增殖,对丁二有一些影响.
- 在BC患者中,PGRMC1表达与瘤大小,等级和转移相关,预测无病和整体存活率较差. 血液中PGRMC1水平与组织表达相关,并且优于CEA,CA125,CA153和TPS.
结论:
- PGRMC1是乳腺癌患者预后的良好预测指标.
- 实验室和动物研究表明,PGRMC1可能在激素替代疗法 (HRT) 期间作为BC风险的预测标志物.
- 在乳腺癌管理和风险评估中,PGRMC1具有作为一种有价值的生物标志物的潜力.
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