在中国对精子捐赠者的基因测试:对当前实践的调查
Chuan Huang1,2, Qi-Lin Wang3, Hui-Lan Wu1
1Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, Hunan, China.
Frontiers in endocrinology
|August 2, 2023
概括
中国的精子银行主要使用型分析来对捐赠者进行查,但患者对更广泛的遗传检测的需求正在增加. 需要加强基因查和训练有素的遗传咨询师来满足这些不断变化的需求.
科学领域:
- 生殖医学 生殖医学
- 人类遗传学 人类遗传学
- 公共卫生政策 公共卫生政策
背景情况:
- 目前的中国法规要求对精子捐赠者进行传染性和遗传性疾病查,包括型分析.
- 现有的遗传查协议可能无法完全满足患者对全面捐赠者遗传信息日益增长的需求.
- 2003年的"人类精子银行管理措施"仍然是指导方针.
研究的目的:
- 调查中国精子银行对精子捐赠者的基因查现行做法.
- 评估这些机构内遗传咨询师的资格和角色.
主要方法:
- 在中国各地的27个人类精子银行进行了电子调查.
- 26家精子银行 (96.3%的响应率) 完成了一项32个问题的调查,详细介绍了他们的基因测试和咨询实践.
- 收集的数据主要集中在查方法,家族史收集和遗传咨询师的可用性.
主要成果:
- 所有26个响应的精子银行都对捐赠者进行型分析.
- 84.6%收集三代家族史;38.5%满足接受者对特定遗传测试的要求.
- 只有7.7%的人使用全外因组测序,73.1%的人有员工遗传咨询师.
结论:
- 显然需要扩大基因测试小组,以适应中国人口.
- 建议对捐赠者和接受者进行大规模的基因查.
- 雇佣经过专业培训的遗传学家作为遗传咨询师对于有效沟通测试结果和影响至关重要.
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