体阶段刺激开始日对双刺激周期的影响
Ana Fuentes1, Cristina García-Ajofrín2, Ruth Romero2
1Department of Reproductive Medicine, Instituto Bernabeu, Alicante, Spain.
Frontiers in endocrinology
|August 2, 2023
概括
在DuoStim周期中,第二次卵巢刺激的时间不会影响获得的卵细胞数量. 然而,晚些时候,在5-6天之间开始刺激,可以改善预后不佳的患者的卵细胞受精和胚胎细胞形成率.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精过程中受精.
- 卵巢刺激协议 卵巢刺激协议
背景情况:
- 双卵巢刺激是接受试管婴儿的不良预后患者的关键策略.
- 这种刺激协议的实施存在显著的异质性.
- 启动第二次刺激阶段的最佳时间尚不清楚.
研究的目的:
- 为了评估在DuoStim循环中启动质期刺激在检索后的不同天对卵巢反应的影响.
- 为了确定第二次刺激开始的日期是否会影响卵细胞产量和质量.
主要方法:
- 从2018年1月到2021年12月,对541个DuoStim周期进行了回顾性分析.
- 根据黄质期刺激的开始日 (0-2,3,4或5-6天后恢复) 将患者分为四组.
- 主要结局:在质期刺激过程中获取的卵细胞数量.
主要成果:
- 在所有组中检索的卵细胞总数没有显著差异.
- 在第4天开始的刺激显示了对更长时间刺激的趋势.
- 当刺激开始在第4天之前时,观察到受精卵细胞数量较少.
- 当第二次刺激在检索后5-6天开始时,获得了更高的囊胚细胞数量.
结论:
- 在DuoStim循环中,第二次刺激的启动日不会影响获得的卵细胞数量.
- 如果第二次刺激在第4天之前开始,则受精和胚胎细胞率表明的卵细胞能力可能会受到损害.
- 优化第二次刺激阶段的时间对于改善预后不佳的试管婴儿患者的结果至关重要.
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