从不同的数据源中整合现实世界的证据,用于健康技术评估
Pooyeh Graili1,2, Jason R Guertin3,4,5, Kelvin K W Chan6,7,8
1Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.
现实世界的证据 (RWE) 可以通过填补证据缺口和了解长期影响来增强健康技术评估 (HTA). 克服挑战是将RWE广泛纳入HTA流程的关键.
科学领域:
- 卫生经济学与研究成果研究成果
- 基于证据的医学基于证据的医学.
- 监管科学 监管科学
背景情况:
- 在整个治疗产品生命周期中,越来越多地使用现实世界的证据 (RWE).
- 然而,在医疗技术评估 (HTA) 过程中,RWE仍未得到充分利用.
- 目前的HTA过程面临证据缺口和医疗技术长期影响的不确定性.
研究的目的:
- 探索从各种真实世界数据 (RWD) 源中广泛整合RWE到HTA.
- 讨论RWE在HTA过程中的最佳应用 (何时,在哪里,以及如何).
- 确定在HTA中使用RWE的潜在挑战和障碍.
主要方法:
- 文献综述和综合利用RWE用于HTA的当前实践和挑战.
- 分析不同的RWD源及其在HTA框架中的适用性.
- 讨论克服RWE整合障碍的战略.
主要成果:
- 电力发电提供了解决证据缺口和减少HTA不确定性的巨大潜力.
- 医疗技术评估机构越来越多地寻找利用各种数据来源利用RWE的方法.
- 显著的挑战和障碍阻碍了将RWE常规纳入HTA.
结论:
- 将RWE更广泛地整合到HTA中对于对医疗技术的知情决策至关重要.
- 为最大限度地提高RWE在HTA中的价值,需要解决已确定的挑战.
- 为了在HTA中有效利用RWE,需要进一步开发可靠的方法.
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