平均肌素尿素清除:复兴一个旧的分析技术?
Luciano Selistre1,2,3,4, Vandréa de Souza3,4, Carla Nicola3
1Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Néphrologie Dialyse, Hypertension et Exploration Fonctionnelle Rénale, Lyon, France.
Clinical kidney journal
|August 2, 2023
概括
使用尿道肌素和尿素清除率 (mClUN-cr) 的平均值估计球透率 (eGFR) 显示出有希望的结果,特别是在具有较低GFR水平的慢性病患者中. 当标准测量无法使用时,这种方法提供了一个有价值的替代方案.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床化学 临床化学
- 生物标志物 生物标志物
背景情况:
- 基于肌素的方程,如CKD-EPI,是估计球过率 (eGFR) 的标准,但在晚期慢性病中不那么准确.
- 很少有研究将EGFR方程与尿路肌素和尿素清除率 (mClUN-cr) 的平均值进行了比较.
研究的目的:
- 为了评估mClUN-cr与CKD-EPI 2009和CKD-EPI 2021等式相比的性能,用于估计膜过率 (eGFR).
主要方法:
- 一项涉及855名参与者的横截面研究.
- 用尿路胰岛素清除率作为参考来测量GFR.
- 使用对mClUN-cr,CKD-EPI 2009和CKD-EPI 2021的偏差,精度和准确性 (P30) 标准来评估性能.
主要成果:
- mClUN-cr的整体性能与CKD-EPI方程相似.
- CKD-EPI方程在GFR>60毫升/分钟/1.73米2时表现最好.
- 在较低的GFR水平 (<60毫升/分钟/1.73米2) 上,mClUN-cr表现优越.
结论:
- mClUN-cr对于估计GFR<60毫升/分钟/1.73米2的患者的GFR特别有效.
- 这种方法为整体队列提供了令人满意的估计.
- mClUN-cr是估计慢性病患者的GFR的一个有价值的工具,特别是在资源有限的环境中,无法使用参考测量.
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