芬太尼在死后病例工作中的兴起和兴起
1Department of Forensic Toxicology, New York City Office of Chief Medical Examiner, New York City, New York, USA.
Journal of forensic sciences
|August 2, 2023
概括
涉及芬太尼的法医毒理病例升,高度在2021-2022年间翻了一番. 代谢物4-ANPP (4-anilino-N-phenethylpiperidine) 可以帮助区分非法芬太尼,而西拉联合检测正在上升.
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
- 公共卫生 公共卫生
背景情况:
- 法医毒理实验室面临着越来越多的药物过量死亡,阿片类药物流行以及新型精神活性物质.
- 纽约市的法医毒理学部门在过去十年里,死后病例工作增加了56%.
- 芬太尼在纽约市所有过量死亡的80%中被检测到.
研究的目的:
- 在死后案件中分析芬太尼和芬太尼类比检测趋势.
- 研究4-ANPP (4-anilino-N-phenethylpiperidine) 作为非法芬太尼的差异化剂的实用性.
- 追踪新芬太尼类同类物质的出现和与之同时出现的物质,如西拉.
主要方法:
- 液体染色学双重质谱法 (LCMSMS) 用于在2.5年内测试15638例死后病例.
- 芬太尼和芬太尼类型在股骨血液样本中得到量化.
- 分析了与芬太尼相对的4-ANPP度.
主要成果:
- 芬太尼在约三分之一的病例中被检测到,高度 (>100 ng/mL) 从2021年到2022年翻了一番.
- 在99.1%的病例中,4-ANPP:芬太尼尔比率为<0.67,而在98%的病例中,4-ANPP水平为<10 ng/mL,这表明它在区分非法来源方面具有实用性.
- 自2020年以来,芳作为主导类型出现了,而与2021年相比,2022年克西拉联合检测增加了36.7%,比2021年增加了36.7%.
结论:
- 芬太尼的流行率和高度病例在纽约市的死后病例工作中显著增加.
- 4-ANPP:芬太尼尔比率是识别非法芬太尼尔使用的有价值标记.
- 新兴的芬太尼类似物和像西拉这样的共毒剂需要在法医毒理学中进行持续监测.
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