低度和高度COVID-19患者倾向于出现令人丧的临床结果
Marko Lucijanic1,2, Ivan Krecak3,4, David Cicic1
1Hematology Department, University Hospital Dubrava, Zagreb, Croatia.
概括
血清度异常,低 (低度) 和高 (高度),在住院COVID-19患者中很常见. 这些情况与严重疾病和死亡风险增加有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
- 临界护理医学 临界护理医学
背景情况:
- 血清度是液体和电解质平衡的关键指标.
- 在各种临床条件下经常观察到血清度的破坏.
- 了解度在COVID-19中的作用对于患者管理至关重要.
研究的目的:
- 调查COVID-19患者入院血清度 (低,高和正常度) 与临床特征之间的关联.
- 为了确定入院血清度对COVID-19患者结果的影响,包括死亡率.
- 探索与严重的COVID-19中度相关的潜在治疗点.
主要方法:
- 对5645名连续住院COVID-19患者的回顾性分析.
- 血清度是用以下公式计算的: 2x Na + 尿素 + 葡萄糖 (mOsm/L).
- 统计分析,包括多变量逻辑回归,以评估与并发病和死亡率的关联.
主要成果:
- 在入院时,42.9%的患者是超位,5.3%是低位,51.8%是正常位.
- 低度与肝脏疾病,恶性瘤和有关.
- 超度与代谢和心血管并发症有关.
- 低和高的患者表现出更严重的COVID-19,更高的炎症,与正常患者相比,死亡率显著增加.
- 低度 (aOR=1.39) 和高度 (aOR=1.9) 独立地预测了更高的死亡率.
结论:
- 在住院的COVID-19患者中,血清度干扰很普遍.
- 低度和高度都是COVID-19死亡率增加的重要独立预测因素.
- 监测和潜在的向血清度可能提供一种治疗策略,以改善COVID-19患者的治疗结果.
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