改变癌症心态:一个随机控制的可行性和有效性试验.
Sean R Zion1, Lidia Schapira2, Jonathan S Berek2,3
1Department of Psychology, Stanford University, Stanford, California, USA.
Psycho-oncology
|August 2, 2023
概括
一项新的数字干预措施改善了癌症患者的生活质量,通过准他们对疾病的看法. 这种癌症思维干预 (CMI) 增强了应对能力,减少了症状困扰,为支持性癌症护理提供了一种新的方法.
科学领域:
- 在瘤学瘤学.
- 数字健康数字健康
- 心理干预 心理干预
背景情况:
- 癌症诊断和治疗显著影响患者的身体,社会,情感和功能生活质量.
- 现有的心理治疗方法往往侧重于特定的症状,而不是整体的患者体验.
- 需要针对患者关于疾病的核心假设进行干预,以改善他们的福祉.
研究的目的:
- 评估一种新的数字干预措施的可行性和有效性,即癌症思维干预 (CMI).
- 评估CMI对新确诊癌症患者的整体健康相关生活质量 (HRQoL) 的影响.
- 检查干预对应对行为和症状困扰的影响.
主要方法:
- 一项分散的临床试验,涉及361名新诊断非转移性癌症的成年患者,正在接受全身治疗.
- 将参与者随机分配到癌症思维干预 (CMI) 组或通常治疗 (TAU) 组.
- 在10周的时间里,CMI组完成了7个在线模块,重点是癌症和与身体有关的思维方式;主要结果是HRQoL.
主要成果:
- CMI组的患者在癌症和身体的适应性思维中表现出显著的改善.
- 与TAU组相比,CMI组报告了整体HRQoL的显著改善 (p < 0.001).
- CMI导致适应性应对行为增加 (p < 0.001) 和减少身体症状困扰 (p < 0.01) 与中等效应大小 (d = 0.420.54).
结论:
- 一个简短的,以思维方式为重点的数字干预有效地改善了新诊断的癌症患者的HRQoL的多个方面.
- 癌症思维干预在增强适应性应对和减少症状困扰方面表现出有效性.
- 这种数字化方法为改善癌症治疗期间整体患者体验提供了一个有希望的策略.
相关概念视频
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Cancer Survival Analysis
384
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
384
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Cancer Vaccines
405
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
405


