在20个月的随访研究中,针对Omicron亚型的第三剂CoronaVac的中和活性在20个月的随访研究中
Cheng Cao1,2, Qin Guo3, Yaping Dai4
1Department of Laboratory Medicine, Jiangnan University Medical Center, Wuxi, JS, China.
Human vaccines & immunotherapeutics
|August 2, 2023
概括
三次CoronaVac剂量可以增强SARS-CoV-2抗体,但在10-12个月内对Omicron亚型变种的中和能力会减弱. 第四剂可能需要持续保护新兴变种.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 针对SARS-CoV-2 Omicron亚型的CoronaVac疫苗接种后抗体反应的持久性尚未得到充分了解.
- 评估长期免疫力对于公共卫生战略至关重要.
研究的目的:
- 为了评估三剂 CoronaVac 疫苗接种方案后抗体反应的持久性.
- 评估20个月内对SARS-CoV-2 Omicron亚变种的中和活性.
主要方法:
- 在20个月的时间里,从32个健康个体获得160个血样本的纵向跟踪.
- 测量SARS-CoV-2 IgG和中和抗体标位.
- 对祖先和Omicron亚变体的中和活动的评估.
主要成果:
- 第三次CoronaVac剂量显著增加了IgG和中和抗体标位,以及对Omicron亚型的中和.
- 抗体水平下降,但在接种疫苗后的10-12个月内仍可检测.
- 对Omicron亚型 (B.1.1.529,BA.2,BA.4/BA.5,BA.2.75.2) 的中和活性在10-12个月内消失,而对祖先菌株的活性仍然存在.
结论:
- 虽然三次CoronaVac剂量诱导了强大的初始抗体反应,但随着时间的推移,对Omicron亚型的中和能力显著下降.
- 潜在的第四剂疫苗剂量可能需要维持有效的中和,以对抗未感染个体中新出现的SARS-CoV-2 Omicron亚变体.
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