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基索基纳米凝的配方和评估,用于口服的迪奥斯

Mohammed Ali Mujtaba¹, Nawaf M Alotaibi²

¹Department of Pharmaceutics, Faculty of Pharmacy, Northern Border University, Rafha Campus, Saudi Arabia.

Pakistan journal of pharmaceutical sciences

|August 2, 2023

概括

基托基纳米凝有效地提供生物活性黄类迪奥斯 (DSN),克服其生物制药方面的局限性. 这些新的药物输送平台显示出卓越的稳定性和DSN的口服输送潜力.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
药物运输药物运输药物运输

背景情况:

迪奥斯 (DSN) 具有显著的生物活性,但面临着生物制药方面的挑战.
需要有效的药物输送系统来增强DSN的治疗优势.

研究的目的:

开发和描述基托基纳米凝 (NGs) 作为迪奥斯 (DSN) 的药物输送平台.
评估DSN载NGs的物理化学特性和体外释放.

主要方法:

使用离子凝方法制备DSN载荷的奇托纳米凝.
物理化学表征包括粒子大小,PDI,泽塔潜力,负载效率和容量.
传输电子显微镜 (TEM) 用于形态分析.
在不同的pH值下进行了体外胀,侵蚀和药物释放研究.

主要成果:

装有DSN的NG的粒子大小为113.07±12.62nm,PDI为0.266±0.08,ZP为22.32±0.56 mV.
负载效率和负载容量分别为81.56±2.65%和10.25±1.43%.
纳米凝显示了pH值依赖的胀和侵蚀,在酸性缓冲中观察到Fickian释放.
该系统在25°C和40°C下90天表现出良好稳定性.

结论:

基托基纳米凝是一种有希望和有效的系统,用于口服 diosmin.
开发的纳米凝克服了迪奥斯的生物制药限制,增强了其治疗潜力.

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