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一种强大的混合充电的紫外线聚氨涂层,与干预性血液接触装置的抗菌和抗凝功能相结合

Jinyu Peng¹, Kaijun Li¹, Yangrui Du¹

¹College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China. lgy3506@scu.edu.cn.

Journal of materials chemistry. B

|August 2, 2023

概括

这项研究为医疗器械开发了一种强大的zwitterionic涂层 (CMPU). 创新的涂层可以防止血栓和细菌感染,提高设备的安全性和有效性.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
表面工程是什么?表面工程是什么?

背景情况:

基聚合物对于血液接触器件的防涂层至关重要.
目前的zwitterionic涂料的粘合稳定性较弱仍然是一个重大挑战.
干预器件需要抗阻血栓和感染的表面.

研究的目的:

开发一种具有增强粘附性和强大的抗/抗菌性质的zwitterionic涂层.
为了解决医疗应用现有齐维特里昂涂层的局限性.
为了提高干预性血液接触器械的生物相容性和安全性.

主要方法:

合成的生物相容的混合电荷齐维特聚氨 (MPU) 聚合物.
开发了一种通过对热塑性聚氨 (TPU) 基板进行浸泡涂层的交叉连接增强MPU (CMPU) 涂层,使用的是一个异形异酸盐交叉连接器 (AIC).
评估了CMPU涂层的机械强度,粘合强度,抗,抗菌和抗凝固性能.

主要成果:

由于AIC诱导的交联,CMPU涂层表现出了出色的机械强度和粘合强度.
特的CMPU涂层表现出显著的抗和抗菌活性,抑制蛋白质吸附和细菌生长.
在没有抗凝剂的ex vivo测试中,CMPU涂层的TPU导管有效地防止了血块形成.

结论:

开发的CMPU涂层为提高干预性血液接触器件性能提供了一个有前途的解决方案.
这种创新的涂层有效地对抗血栓和感染,这对医疗器械安全至关重要.
CMPU涂层具有巨大的潜力,通过减少与设备相关的并发症来改善患者的治疗结果.

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