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[关于确定乳腺癌分子生物学亚型的更新的CAP指南]

L E Zavalishina¹, E M Oliushina¹, Yu Yu Andreeva¹

¹Russian Medical Academy of Continuous Professional Education, Moscow, Russia.

Arkhiv patologii

|August 2, 2023

概括

2023年美国病理学家学院的指导方针更新了测试雌激素受体 (ER),孕激素受体 (PgR) 和乳腺癌中的HER2的建议. 针对低受体表达的新术语"ER低阳性"和"HER2低"被引入.

科学领域:

在瘤学瘤学.
病理学病理学病理学
分子诊断学分子诊断

背景情况:

精确评估激素受体 (ER,PgR) 和HER2状态对于乳腺癌治疗决策至关重要.
免疫组织化学 (IHC) 是评估这些生物标志物的标准方法.
随着对受体表达的不断发展的理解,需要更新指南.

研究的目的:

提出2023年更新的美国病理学家学院 (CAP) 准则,用于乳腺癌中IHC检测ER,PgR,HER2和Ki-67.
突出介绍了低水平受体表达的新术语的引入.

主要方法:

审查和综合当前证据和专家共识.
制定IHC测试程序和解释的最新建议.
包括定义"ER低阳性"和"HER2低"瘤的标准.

主要成果:

更新的指导方针为HER2,ER,PGR和Ki-67测试提供了标准化的协议.
引入"ER低阳性"和"HER2低"类别来分类具有低生物标志物表达的瘤.
强调对IHC结果的一致解释和报告.

结论:

更新的CAP指南旨在提高乳腺癌生物标志物测试的准确性和一致性.
新的"ER低阳性"和"HER2低"分类为乳腺瘤提供了更细致的特征.
遵守这些准则预计将加强乳腺癌患者的个性化治疗策略.

关键词:

ER表达式 ER表达式 ER表达式 HER2 低低低在HER2表达的过程中,Ki-67的表达方式在PgR表达式中,乳腺癌乳腺癌乳腺癌人类表皮生长因子受体2型

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