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相关概念视频

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Synthesis and Regulation of Thyroid Hormones01:20

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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The Thyroid Gland01:23

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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儿童甲状腺功能的遗传决定因素

Tessa A Mulder1,2,3, Purdey J Campbell4, Peter N Taylor5

  • 1Generation R Study Group, Erasmus University Medical Center, Rotterdam, CA 3000, The Netherlands.

European journal of endocrinology
|August 2, 2023
PubMed
概括

影响甲状腺刺激激素 (TSH) 和自由甲状腺素 (FT4) 的遗传因素存在于儿童时期,有些影响比成人更大. 这项研究揭示了早期的甲状腺功能遗传调节.

关键词:
童年的童年 童年的童年遗传风险评分 遗传风险评分遗传变异是一种遗传变异.甲状腺功能 甲状腺功能

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科学领域:

  • 内分泌学 在内分泌学.
  • 遗传学 遗传学 是一个
  • 儿科 儿科 儿科

背景情况:

  • 全基因组关联研究已经确定了许多与成年人甲状腺刺激激素 (TSH) 和自由甲状腺素 (FT4) 度相关的遗传位置.
  • 这些遗传决定因素对甲状腺功能的年龄相关影响尚未被彻底研究.

研究的目的:

  • 调查TSH和FT4先前确定的遗传决定因子与新生儿和儿童中这些激素度的关联.
  • 评估基因变异对甲状腺功能影响的潜在年龄相关变异.

主要方法:

  • 利用了来自三个潜在的基于人口的队列的数据:R世代,父母和儿童的艾文纵向研究 (ALSPAC) 和布里斯班纵向双胞胎研究 (BLTS).
  • 使用多变量线性回归分析了单核酸多态 (SNPs) 和TSH/FT4度之间的关联.
  • 构建加权多基因风险评分 (PRS) 来聚合SNP影响.

主要成果:

  • 在儿童时期,SNP的很大一部分 (TSH为30/60,FT为11/31) 经过多次测试校正后显示与甲状腺功能有关.
  • 特定基因 (AADAT,GLIS3,TM4SF4,VEGFA) 的效应大小在儿童中明显大于成人.
  • TSH和FT4 PRS解释了度变化的很大一部分 (TSH为5.3%-8.4%,FT为1.5%-4.2%).
  • 五个TSH相关SNP在新生儿中显示出相关性,而在这个年龄组中没有发现FT4相关SNP.

结论:

  • 许多已知影响甲状腺功能的遗传变异已经在儿童时期活跃.
  • 某些遗传决定因素对甲状腺激素的影响在儿童中可能比成人更明显.
  • 这些发现为早期发育过程中甲状腺功能的遗传调节提供了新的见解.