Milletdb:一个多omics数据库,以加速功能基因组学和小米的分子育种的研究
Min Sun1, Haidong Yan1,2,3, Aling Zhang1
1College of Grassland Science and Technology, Sichuan Agricultural University, Chengdu, China.
Plant biotechnology journal
|August 2, 2023
概括
一个新的Milletdb平台提供了针对小麦的综合性多omics数据,有助于发现与压力相关的基因并提高作物弹性. 该资源支持分子育种和粮食安全倡议.
科学领域:
- 农业科学 农业科学
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- 麦芽是重要的营养丰富的粗谷物,对容易受到压力的地区的粮食安全至关重要.
- 它们对非生物压力的抵抗力使它们成为改善作物的宝贵遗传资源.
- 缺乏集成的多omics平台阻碍了对压力反应基因的识别和小米的分子繁殖.
研究的目的:
- 开发一个全面的,用户友好的,多omics数据库,用于千叶.
- 为了促进与压力相关的基因的挖掘,并支持分子繁殖的努力.
- 为小米基因组学和功能分析提供一个集中平台.
主要方法:
- 开发了Milletdb网络可访问平台 (http://milletdb.novogene.com).
- 整合了6种小米物种和1种相关物种的基因组数据.
- 包括基于图表的珍珠小米泛基因组学和多基因组学数据,包括在不同压力条件下产量特征的GWAS结果.
主要成果:
- Milletdb提供了对基因组,泛基因组和广泛的与压力相关的多基因组数据的访问.
- 在田间,早期干旱和晚期干旱条件下存储了20种产量特征的全基因组关联研究 (GWAS) 数据.
- 该平台确定了一种特定的基因 (PMA1G03779.1),有可能调节产量和应激反应,并揭示了小米加入中PLATZs TFs的扩张.
结论:
- Milletdb是目前可用的最完整的小米多omics数据库,简化了功能基因组学分析.
- 该平台提供20种分析工具,包括基因映射和丰富分析.
- Milletdb使研究人员能够在关键基因发现,基因组编辑和小米的分子育种方面发挥作用,提高作物弹性和粮食安全.
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