皮肤神经内分泌粘性癌是低度的,但可能与其他癌症有关
Kathryn E Adkins1, Klaus Busam, Melissa Pulitzer
1Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
The American journal of surgical pathology
|August 2, 2023
概括
皮肤副瘤中的神经内分泌分化可以使用胰岛素瘤相关蛋白1 (INSM1) 进行评估. 阴性INSM1瘤显示中级行为,而INSM1阳性瘤显示低级行为与其他癌症的潜在风险.
科学领域:
- 皮肤病理学 皮肤病理学
- 在瘤学瘤学.
- 神经内分泌瘤 神经内分泌瘤
背景情况:
- 主要皮肤粘膜汗腺癌的预后历来依赖于较旧的神经内分泌分化标志物.
- 像胰岛素瘤相关蛋白1 (INSM1) 这样的更新,更敏感的标记物为附瘤提供了更好的诊断能力.
研究的目的:
- 为了评估INSM1表达在粘膜和非粘膜附瘤.
- 为了将INSM1表型与临床病理特征和患者结果相关联.
- 重新评估皮肤副瘤中神经内分泌分化的预后意义.
主要方法:
- 对12例皮肤上腺癌/腺癌病例的回顾性分析.
- 针对INSM1,雌激素受体 (ER) 和孕激素受体 (PR) 的免疫组织化学染色.
- INSM1状态与临床病理学数据的相关性,包括结节转移,淋巴血管侵入 (LVI) 和患者随访.
主要成果:
- 大多数粘膜附带瘤 (6/9) 是INSM1阳性,没有LVI或转移.
- 在INSM1阴性粘膜性 (3/9) 和非粘膜性 (3/3) 瘤中,有结节转移和/或LVI的中间行为.
- 具有INSM1阳性的瘤是ER/PR阳性的;患有这些瘤的患者患其他皮肤外恶性瘤的风险增加.
结论:
- INSM1是将皮肤副癌分为神经内分泌和非神经内分泌类型的有价值标记.
- 在INSM1阴性副癌中,表现为中等级的行为.
- 常规INSM1评估和长期癌症查建议在INSM1阳性皮肤附带瘤患者.
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