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在患者中评估细胞复合体和视网膜神经纤维层稀薄的评估
Mustafa Duran1, Serdar Aykaç2, Sinan Eliaçık2
1Department of Ophthalmology, Minister of Health Hitit University Erol Olçok Education and Research Hospital, Çorum, Turkey.
Indian journal of ophthalmology
|August 2, 2023
概括
与健康人相比,患者的细胞复合体 (GCC) 和视网膜神经纤维层 (RNFL) 显著稀薄. 光学连贯断层扫描 (OCT) 可以检测的这些早期视网膜变化.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 是一种神经系统疾病,影响着全世界数以百万计的人.
- 在各种神经疾病中观察到视网膜变化,包括质细胞综合体 (GCC) 和视网膜神经纤维层 (RNFL) 的稀薄.
- 光学连贯断层扫描 (OCT) 是一种非侵入性成像技术,可以对视网膜进行详细的横截面可视化.
研究的目的:
- 为了比较患者和健康对照者的周围GCC和周围RNFL厚度.
- 调查潜在的视网膜生物标志物,以早期检测与相关的变化.
主要方法:
- 一项涉及38名患者 (服用抗药1年以上) 和38名健康对照者的比较研究.
- 使用OCT成像测量了中央斑点厚度,周围斑点GCC厚度和体积以及周围斑点RNFL厚度.
- 测量是在特定的周圆径 (1,3,6毫米) 和象限进行的.
主要成果:
- 与对照组相比,患者在上方象限 (3毫米) 和所有象限 (6毫米) 中显著减少了GCC厚度 (P <0.05).
- 仅在患者的时间下象限中 (P <0.05) 才观察到RNFL显著稀薄.
- 在接受抗药物单疗和多疗 (P > 0.05) 的患者之间,没有发现视网膜测量的显著差异.
结论:
- 与周围眼GCC和特定周围毛囊RNFL象限的显著稀释有关.
- OCT成像,特别是围眼GCC的成像,显示出对患者早期视网膜变化的监测有前途.
- 这些发现凸显了OCT作为一种理解和潜在管理等神经疾病的工具的潜力.
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