与3,4-甲基二氧化甲胺相关的声明性记忆障碍的功能连接体
Rebecca C Coray1,2, Josua Zimmermann1,2, Amelie Haugg3
1Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Human brain mapping
|August 2, 2023
概括
慢性3,4-甲基二氧化甲胺 (MDMA) 使用会通过改变大脑连接来损害记忆力. MDMA使用者在听觉网络中的连接性降低,在注意网络中的连接性增加,影响记忆性能.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 神经成像是一种神经成像.
背景情况:
- 慢性3,4-甲基二氧化甲胺 (MDMA) 的使用与持续的宣言性记忆缺陷有关.
- 这些记忆障碍的潜在神经功能机制仍然不清楚.
研究的目的:
- 为了研究与慢性MDMA使用者的声明性记忆障碍相关的大脑连接性改变.
- 使用静止状态功能磁共振成像 (rs-fMRI) 探索记忆缺陷的神经功能基础.
主要方法:
- 招募了44名慢性MDMA使用者和41名人口统计相匹配的对照.
- 通过使用Rey听觉口头学习测试和视觉关联学习测试来评估声明性记忆.
- 在rs-fMRI数据上使用多声元模式分析 (MVPA) 来分析全脑连接.
主要成果:
- MDMA使用者在任务中表现出明显较低的延迟召回性能.
- MVPA在左后中枢环中发现了显著的全球连接差异.
- 吸食者表现出对时间听觉区域的低连接性和对背顶侧侧侧注意区域的超连接性.
结论:
- 与MDMA相关的记忆障碍与听觉网络和左侧中后回形内的多式感官集成发生变化有关.
- 认知控制网络中的超连接性可能代表MDMA使用者的感官处理缺陷的补偿机制.
关键词:
这是MDMA,MDMA.MVPA MVPA是什么意思审计网络的审计网络.认知控制网络是一个认知控制网络.影像成像技术 影像成像技术记忆的整合 记忆的整合血清胺 (serotonin) 是一种神经元.兴奋剂是一种刺激剂.语言记忆 语言记忆更多相关视频
相关概念视频
Role of Hippocampus in Memory
328
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
328
Role of Cerebellum and Prefrontal Cortex in Memory
484
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
484
Higher Mental Functions of Brain: Learning and Memory
877
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
877
Dissociative Disorders
150
Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
150
Dissociative Amnesia
143
Dissociative amnesia is a complex psychological condition that manifests as an inability to recall personal information, often tied to traumatic or stressful events. Unlike general amnesia, individuals with this condition retain the ability to perform routine activities and procedural tasks, such as operating a phone or navigating public transportation, yet experience profound gaps in autobiographical memory. These lapses may encompass significant life events, such as suicide attempts or...
143
Role of Neurotransmitters in Memory
630
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
630


