- - 引发了大鼠代谢和肠道微生物群的变化
Yong-Xiang Wang1, Jin-Ying Zhang1, Yu-Min Cao1
1College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan Province 450046, P. R. China.
The American journal of Chinese medicine
|August 2, 2023
概括
这项研究揭示了葡萄酒加工的Rhizoma coptidis (wCR),生加工的CR (zCR) 和evodia加工的CR (eCR) 如何影响肠道健康. 每种加工形式都为肠道微生物群和代谢物提供了独特的好处,有助于治疗胃肠道疾病.
科学领域:
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 根 (Rhizoma coptidis,简称CR) 是一种用于治疗胃肠道问题的传统草药.
- 经过加工的形式,如葡萄酒加工的CR (wCR),纤维加工的CR (zCR) 和evodia加工的CR (eCR),具有不同的治疗用途.
- 这些加工CR变体的特定机制需要进一步调查.
研究的目的:
- 为了比较wCR,zCR和eCR在老鼠中的不同干预机制.
- 通过综合便代谢学和16S rDNA基因测序来阐明这些机制.
- 为了解传统中国草药的加工机制提供科学基础.
主要方法:
- 从对照和CR/wCR/zCR/eCR组中的老鼠收集了便样本.
- 使用UHPLC-Q/TOF-MS进行了代谢分析,以确定改变的代谢物.
- 16S rDNA基因测序分析了肠道微生物群的组成,并补充了KEGG通路和PICRUSt2的功能预测.
主要成果:
- wCR在免疫平衡,糖解促进和降低胆固醇方面表现出好处.
- zCR在保护肠道粘液屏障,预防胃以及降低胆固醇方面表现出色.
- eCR在保护肠道粘液屏障完整性和促进糖解方面表现出有效性.
结论:
- 这项研究通过便代谢物和肠道微生物群分析,科学阐明了wCR,zCR和eCR的机制.
- 这些发现为Rhizoma coptidis的处理机制提供了新的见解.
- 每个加工的CR变体的独特效果突出显示了它们针对胃肠道疾病的向治疗潜力.
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