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阿卡利法 (Acalypha australis) L. 提取物通过调节炎症因子释放和阻断NF-κB激活来减轻小鼠DSS诱导的性结肠炎

Bo Chen^1,2, Yiqing Wang³, YouYa Niu⁴

¹College of Biology and Food Engineering, Huaihua University, Huaihua, China.

Journal of medicinal food

|August 2, 2023

概括

在治疗性结肠炎 (UC) 方面,Acalypha australis L. 提取物 (AAL) 是有前途的. 这种天然疗法通过抑制NF-κB通路来减少结肠损伤,炎症和亡.

科学领域:

胃肠病学胃肠病学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

性结肠炎 (UC) 是一种慢性炎症性肠病,治疗选择有限.
UC的确切原因和机制在很大程度上是未知的,这阻碍了有效的治疗方法.
在传统中医药中使用的Acalypha australis L. (AAL) 提取物已显示出抗炎性质.

研究的目的:

在小鼠模型中研究AAL水性提取物对性结肠炎的治疗作用.
探索AAL在UC治疗中的作用的潜在分子机制.

主要方法:

诱导UC的小鼠被用AAL水性提取物 (20mg/kg) 治疗了七天.
对结肠组织进行了损伤 (CMDI),亡和细胞因子释放 (IL-2,IL-8,IL-17A,IL-22,IFN-γ,TNF-α) 的分析.
评估了NF-κB通路相关蛋白质的表达.

主要成果:

AAL治疗显著改善了结肠粘膜损伤指数 (CMDI) 并减少了结肠损伤.
AAL显著降低了促炎性细胞因子 (IL-2,IL-8,IL-17A,IL-22,IFN-γ,TNF-α) 的血清水平.
AAL减少了结肠亡,并抑制了NF-κB通路蛋白的表达.

结论:

阿卡利法 (Acalypha australis L.) 水性提取物对小鼠的性结肠炎表现出显著的保护作用.
通过抑制NF-κB信号通路并减少炎症性细胞因子的释放,AAL发挥了其治疗效益.
性结肠炎 (AAL) 是一种潜在的新型治疗剂,用于治疗性结肠炎.

关键词:

在澳大利亚的Acalypha L.在 DSS 中使用 DSS.通过NF-κB路径.这是一种炎症性炎症.性结肠炎是一种

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