抗高血压药物和PTSD在创伤队列中的发生率
Jaimie L Gradus1,2,3, Meghan L Smith1, Péter Szentkúti4
1Department of Epidemiology, Boston University School of Public Health, Massachusetts.
The Journal of clinical psychiatry
|August 2, 2023
概括
通道阻塞剂可能有助于预防创伤后创伤后应激障碍 (PTSD). 这项研究发现,与其他类别不同,这些抗高血压药物减少了PTSD发生率.
科学领域:
- 药理学 药理学是指药理学的学科.
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 由于PTSD和心血管疾病之间的联系,正在探索抗高血压药物用于PTSD预防.
- 现有证据表明它们在预防PTSD方面的有效性是不确定的.
研究的目的:
- 调查四类抗高血压药物与创伤后应激障碍 (PTSD) 发生率之间的关联.
- 评估β阻塞剂,ARBs,ACE抑制剂和通道阻塞剂在预防创伤事件后PTSD方面的潜力.
主要方法:
- 在丹麦 (1994-2016) 开展了一项基于全国人口的队列研究,涉及超过140万个人.
- 使用ICD-10诊断的PTSD发病率分析与在创伤事件发生前60天内填写的抗高血压药物处方相关.
- 考克斯比例危险回归被用来比较暴露和未暴露组之间的PTSD率.
主要成果:
- 通道阻塞剂与PTSD发病率降低具有统计学意义的关联 (调整后的危险比率=0.63).
- 其他类型的抗高血压药物 (β-阻断剂,ARB,ACE抑制剂) 与PTSD发生率的关联是零或接近于零.
结论:
- 通道阻塞剂需要进一步调查,作为创伤后PTSD的潜在预防措施.
- 需要进行额外的研究和复制研究,以澄清有关抗高血压药物和PTSD预防的各种发现.
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