在复发性EBV阳性淋巴细胞恶性瘤中使用纳尼和瓦尔甘西克洛维尔的向治疗:一项1b/2期研究
Bradley Haverkos1, Onder Alpdogan2, Robert Baiocchi3
1Division of Hematology, University of Colorado, Denver, CO.
Blood advances
|August 2, 2023
概括
这项研究表明,结合纳胺和瓦尔甘克洛维尔是对艾普斯坦-巴尔病毒阳性淋巴瘤的有效治疗方法,为复发或耐药性疾病患者提供了希望.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 病毒学 病毒学
背景情况:
- 爱斯坦-巴尔病毒 (EBV) 与淋巴瘤有关,往往导致较差的结果.
- 纳纳提诺斯塔特是一种基斯脱乙酶抑制剂,可以激活EBV的溶性蛋白,并使瘤细胞对甘西克洛维尔敏感.
研究的目的:
- 评估纳尼诺与瓦尔甘克洛维尔联合治疗复发/耐药EBV阳性淋巴瘤患者的安全性和有效性.
- 为了确定该组合治疗的推第二阶段剂量 (RP2D).
主要方法:
- 一项1b/2期研究招募了55名EBV阳性淋巴瘤患者.
- 第1b阶段涉及剂量升级,以找到RP2D.
- 第二阶段使用了RP2D (纳纳诺斯塔特20毫克/天,每周4天+瓦尔根西克洛维尔900毫克/天) 在30名患者身上进行28天的循环.
主要成果:
- 在43名可评估患者中观察到40%的整体响应率 (ORR),完整响应率 (CRR) 为19%.
- 在血管免疫原性T细胞淋巴瘤-NHL中,ORR为60%,CRR为27%.
- 常见的不良事件包括恶心和细胞衰竭 (中性质衰竭,血小板衰竭,贫血).
结论:
- 纳纳替诺斯塔和瓦尔甘克洛维尔的组合在各种EBV阳性淋巴瘤亚型中显示出令人鼓舞的疗效.
- 这种新的口服治疗方案需要在确认性研究中进一步调查.
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