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Updated: Jul 20, 2025

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用VX-548对急性疼痛进行NaV1.8的选择性抑制

Jim Jones1, Darin J Correll1, Sandra M Lechner1

  • 1From Vertex Pharmaceuticals (J.J., D.J.C., S.M.L., I.J., X.M., D.S., C.S., J.D.O., B.H., C.B., P.N.) and Brigham and Women's Hospital (S.G.W.) - both in Boston; Lotus Clinical Research, Pasadena (A. Beaton), Cedars-Sinai Medical Center, Los Angeles (P.F.W.), and White Mountain Institute, Sea Ranch (P.F.W.) - all in California; JBR Clinical Research, Salt Lake City (T.B.); Rush University Medical Center, Chicago (A. Buvanendran); Duke University School of Medicine, Durham, NC (A.S.H.); the University of Pittsburgh Medical Center, Pittsburgh (L.J.P.); and Endeavor Clinical Trials, San Antonio, TX (R.A.P.).

The New England journal of medicine
|August 2, 2023
PubMed
概括

高剂量的VX-548有效地减少了手术后的急性疼痛,超过了安慰剂. 较低剂量的VX-548没有显著缓解疼痛,报告的副作用轻微,如头痛和便秘.

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