在成年人中切除甲状腺体的健康后果
Kameron A Kooshesh1, Brody H Foy1, David B Sykes1
1From the Centers for Regenerative Medicine (K.A.K., D.B.S., K.G., D.T.S.) and Systems Biology (B.H.F.), Massachusetts General Hospital, the Harvard Stem Cell Institute (K.A.K., K.G., D.T.S.), the Department of Stem Cell and Regenerative Biology, Harvard University (K.A.K., K.G., D.T.S.), and Harvard Medical School (K.A.K., B.H.F., D.B.S., K.G., D.T.S.) - all in Boston.
The New England journal of medicine
|August 2, 2023
概括
在成年人中切除甲状腺会增加死亡,癌症和自身免疫性疾病的风险. 这项研究表明,成年人胸腺对于免疫能力和长期健康至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 成人的甲状腺功能 成人的甲状腺功能
- 外科手术的结果
背景情况:
- 成人胸腺在维持免疫功能和整体健康方面的作用尚不清楚.
- 胸腺通常在各种心胸外科手术过程中被切除.
研究的目的:
- 为了研究成年人甲状腺切除术的长期健康后果.
- 为了确定成人胸腺是否对持续的免疫能力至关重要.
主要方法:
- 一项比较性研究评估了成年甲状腺切除术患者的死亡率,癌症发病率和自身免疫性疾病风险,与匹配的对照对比.
- 在一小组患者中分析T细胞生产和血细胞因子水平.
主要成果:
- 胸膜切除术与在手术后5年显著增加全因死亡率 (RR 2.9) 和癌症风险 (RR 2.0) 相关.
- 在排除那些患有先前存在的疾病后,在甲状腺切除患者中观察到自身免疫性疾病的风险增加 (RR 1.5).
- 在经过小肠切除的个体中,发现了新的T细胞 (CD4+和CD8+) 生产的减少和高水平的促炎细胞因子.
结论:
- 成年人乳腺切除术与长期死亡率增加和癌症风险增加有关.
- 胸腺缺失可能会损害免疫监测,可能增加自身免疫性疾病的风险.
- 这些发现凸显了成年人胸腺对于维持健康和免疫功能的重要性.
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