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通过使用不同的水化方案和对酸补充剂的元分析,对预防西斯普拉丁诱导的毒性进行系统审查
Juanjuan Li1, Yu Wu1, Cheng Chen1
1Division of Nephrology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, 68 Gehu Road, Hutang Town, Wujin District, Changzhou, Jiangsu, China.
Clinical and experimental nephrology
|August 2, 2023
概括
在水合期间补充可能会防止西斯产生的毒性 (CIN),这是化疗的严重副作用. 这一元分析表明,是一种潜在的有效干预措施,可以预防接受西斯的患者的脏损伤.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 西斯是一种重要的化疗剂,但会引起显著的毒性,影响多达20%的患者.
- 西斯普拉丁诱导的毒性 (CIN) 限制了治疗疗效和患者的治疗结果.
- 像补充这样的干预措施正在被探索以减轻CIN.
研究的目的:
- 审查用于预防CIN.IN的水化方案.
- 进行补充剂对CIN的保护作用的元分析.
主要方法:
- 在PubMed,Embase和Cochrane数据库中进行系统搜索.
- 包括涉及西斯普拉丁的试验,以及用于预防CIN的水分管理方案.
- 使用几率比率 (OR) 和95%置信区间 (CI) 的元分析来评估疗效.
主要成果:
- 从最初的1113个确定的研究中,包括了33项研究.
- 进行了对11项关于补充的回顾性研究的元分析.
- 在水合期间补充,对CIN有显著的保护 (OR=0.22,95%CI=0.14到0.35).
结论:
- 预防CIN的最佳方法仍然不确定.
- 在水合期间补充显示出对CIN的潜在保护作用.
- 在PROSPERO注册的研究 (CRD42020212682).
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