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高压氧气治疗对角膜内皮结构和前段参数的影响

Murat Garlı¹, Tuncay Küsbeci¹, Figen Aydın²

¹Department of Ophthalmology, University of Health Sciences, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.

Cutaneous and ocular toxicology

|August 2, 2023

概括

高压氧化疗 (HBOT) 在健康眼睛中没有显著改变角膜结构或前段参数. 然而,HBOT可能会在20个会话后导致球体等价值 (SE) 显著下降.

科学领域:

眼科医生眼科眼科
高压医学的高压医学.
角质科学角质科学

背景情况:

高压氧气疗法 (HBOT) 涉及到在加压室中呼吸纯氧气.
它对眼睛结构,特别是角膜的影响尚未完全理解.

研究的目的:

评估HBOT对角膜内皮结构和健康眼睛前部段参数的影响.
评估中枢角膜厚度 (CCT),内皮细胞密度 (ECD),眼内压力 (IOP) 和其他眼睛指标的变化.

主要方法:

一项前性研究涉及17个健康的眼睛接受HBOT治疗非眼科疾病.
使用光镜显微镜测量了CCT,ECD,平均细胞面积 (AVG),变化系数 (CV) 和六角细胞 (HEX).
在第1次和第20次HBOT疗程之前,第1次和第20次HBOT疗程之后,记录了IOP,球形等效 (SE),轴长 (AL) 和前腔深度 (ACD).

主要成果:

在HBOT后,没有观察到CCT,ECD,AVG,CV或HEX的统计学意义上的变化.
平均IOP和ACD在HBOT疗程后显示非显著下降.
在20次HBOT疗程 (p=0.009) 后,发现SE的统计显著减少.

结论:

在健康的眼睛中,HBOT似乎没有显著影响角膜内皮结构或前段形态.
虽然IOP和ACD可能会略有下降,但这些变化在统计学上并不显著.
在20个HBOT疗程后,SE的潜在显著减少需要进一步调查.

关键词:

高压氧疗法高压氧疗法角膜内皮层角膜内皮层内皮细胞密度内皮细胞密度眼内压力眼内压力镜像显微镜镜像显微镜镜像显微镜

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