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Updated: Jul 20, 2025

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终端基因修饰的DNA Aptamers具有增强的蛋白质结合亲和力

Eric M Kohn¹, Kirill Konovalov^1,2, Christian A Gomez¹

¹Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.

ACS chemical biology

|August 2, 2023

概括

终端基因增强了DNA体对蛋白质的结合. 这种修改导致了DNA胺体与血栓结合的结合率提高了3.2倍,从而提高了药物发现潜力.

科学领域:

生物化学生物化学
分子生物学分子生物学
药物发现药物发现药物发现

背景情况:

胺是基于核酸的受体,提供快速发现和制造.
蛋白质受体 (例如抗体) 具有多样化的功能组,而体缺乏这些功能组.
无生物功能群可以增强DNA体结合亲和力,而甲等芳香基则显示出有前途.

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