在患有自身免疫性疾病的怀孕中评估胎儿心脏功能:一项前性病例控制研究
Muradiye Yildirim1, Deniz Oluklu1, Dilek Menekse Beser1
1Department of Obstetrics and Gynecology, Division of Perinatology, Turkish Ministry of Health Ankara City Hospital, Ankara, Türkiye.
Journal of perinatal medicine
|August 2, 2023
概括
患有自身免疫性疾病 (AID) 的怀孕显著影响胎儿心脏功能. 氧化 (HCQ) 可能为患有艾滋病的母亲的胎儿提供保护性心血管益处.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 怀孕期间的自身免疫性疾病 (AID) 对母亲和胎儿都有风险.
- 在AID的炎症过程可能会影响胎儿发育,包括心血管功能.
- 了解这些影响对于有效的产前护理和管理至关重要.
研究的目的:
- 评估自身免疫性疾病对胎儿心脏功能的影响.
- 为了调查氧化 (HCQ) 对胎儿心脏健康的潜在治疗效果,在怀孕中因艾滋病而复杂.
主要方法:
- 这是一项前性研究,涉及36名被诊断患有艾滋病的孕妇 (SLE,APS,Sjögren's) 和72名健康对照.
- 使用脉冲波,组织多普勒和M模式回声心脏成像来评估胎儿心脏功能.
- 分析包括标准心声学参数和心肌性能指数.
主要成果:
- 患有AID的孕妇表现出胎儿心脏功能的显著改变,包括三管流入,透静功能 (E/A,E'/A') 和心肌性能的变化.
- 观察到三状环状平面缩外流 (TAPSE) 和缩速度 (S') 的显著下降.
- 与非使用者相比,暴露于氧化 (HCQ) 的胎儿显示出改善的E'速度和降低的E/E'比率.
结论:
- 自免疫性疾病在怀孕期间显著影响胎儿心脏功能.
- 氧化 (HCQ) 可能对艾滋病患母亲胎儿的心血管健康产生积极影响.
- 这些发现可以指导临床医生在受自身免疫性疾病影响的怀孕中管理心血管风险.
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