拉维多米辛来自Streptomyces sp. 的类似物. 表现出改变的抗微生物和细胞毒性选择性
Kyoung Jin Park1, Sarah Maier1, Chengqian Zhang1
1Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
Journal of natural products
|August 2, 2023
概括
研究人员发现了六种新的拉维多米辛类似物和新型天然产品fucomycin V. 这些化合物及其类似物经过对生物活性进行测试,在几个衍生品中显示出增强的抗菌选择性.
科学领域:
- 自然产品化学 自然产品化学
- 微生物学 微生物学
- 药用化学 医学化学
背景情况:
- 拉维多米辛及其类似物是已知的具有潜在生物活性的天然产品.
- 新型类型的隔离和表征可以导致发现新的治疗剂.
- 探索微生物代谢物对于识别各种化学结构至关重要.
研究的目的:
- 从Streptomyces sp.中分离和描述新的拉维多米辛类型和福科米辛V. 这就是Am59.
- 用光谱和计算方法阐明分离化合物的结构.
- 评估新型化合物的抗菌,抗真菌和细胞毒性活动.
主要方法:
- 紫外线和LCMS引导的分离技术.
- 全球自然产品社会 (GNPS) 分子网络分析.
- 为结构阐明进行光谱 (NMR,MS) 和计算分析.
- 特定旋转的确定和与文献价值的比较.
- 生物活性测定包括抗菌,抗真菌和细胞毒性测试.
主要成果:
- 分离和鉴定了六种新的拉维多米辛类型 (1-4,6,7) 和福科米辛V (9) 的特征.
- 此外,还发现了四种新型的类型 (10-13) 的福科米辛V.
- 鉴定并纠正了报告的 deacetylravidomycin 特定旋转中的不一致性.
- 化合物4-6 ,9 ,11和12与甲基乙拉维多米辛相比显示出增强的抗菌选择性.
结论:
- 这项研究扩大了与拉维多米辛相关的天然产品的化学多样性.
- 第一次报告说Fucomycin V作为一种天然产品.
- 脱乙拉维多米辛的纠正的特定旋转提供了有价值的立体化学信息.
- 几种分离的化合物表现出有前途的抗菌选择性,为药物开发需要进一步的研究.
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