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Circadian Entrainment of Drosophila Melanogaster
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通过Drosophila中的时钟介导的Gart调节食和能量恒温
Lei He1, Binbin Wu2, Jian Shi1
1Department of Entomology and MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing 100193, P.R. China.
Cell reports
|August 2, 2023
概括
该基因Gart调节了Drosophila的食行为和能量平衡. 它的表达,由CLOCK/CYCLE控制,影响食节奏,影响动物的寿命.
科学领域:
- 动物生理学 动物生理学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 养行为对于动物的生长和生存至关重要,但其潜在的分子机制在很大程度上仍未被探索.
- 了解养行为的调节是解决代谢障碍和延长寿命的关键.
研究的目的:
- 为了研究Gart基因在Drosophila中调节养行为和能量恒温的作用.
- 阐明调节Gart表达的分子通路和转录调节及其对寿命的影响.
主要方法:
- 在Drosophila的各种组织 (质细胞,脂肪体,肠道) 中分析Gart的表达.
- 功能性研究评估Gart对食节律,食物摄入量和能量代谢的影响.
- 通过CLOCK/CYCLE异构体对Gart的转录调节的研究.
主要成果:
- 体表达在质细胞,体脂肪和肠道中,通过协调行动积极调节食行为.
- 肠道中的Gart对于维持食节奏和控制食物摄入量至关重要.
- 质细胞和脂肪体中的调节能量恒温,影响多虫的寿命.
- 关节表达通过E-box元件直接由CLOCK/CYCLE控制,在外围组织和大脑中通过CLOCKs进行差异调节.
结论:
- 在协调养行为,能量恒温和延长Drosophila的寿命方面发挥着至关重要的作用.
- CLOCK/CYCLE异构体对Gart的表达有复杂的控制,突出了复杂的调节网络.
- 这项研究为营养调节的分子基础及其对寿命的影响提供了新的见解.
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