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患有扩散性大B细胞淋巴瘤和精神疾病的患者的死亡率:基于人口的研究
Inna Y Gong1, Matthew C Cheung1,2,3, Kelvin K W Chan1,2,3,4
1Department of Medicine, University of Toronto, Toronto, ON, Canada.
Journal of the National Cancer Institute
|August 2, 2023
概括
患有扩散性大B细胞淋巴瘤 (DLBCL) 和精神疾病的患者面临死亡率增加. 诊断后的精神障碍显著恶化DLBCL患者的短期和长期生存率.
科学领域:
- 在瘤学瘤学.
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 在扩散性大B细胞淋巴瘤 (DLBCL) 患者中观察到精神障碍.
- 有限的研究存在于精神疾病和DLBCL死亡率之间的关联.
研究的目的:
- 调查DLBCL患者精神疾病和死亡率之间的关系.
- 区分预先存在的精神障碍与诊断后精神障碍对生存的影响.
主要方法:
- 在加拿大安大略省使用链接的行政医疗保健数据库进行基于人口的研究.
- 包括DLBCL患者 (≥18岁) 接受基于rituximab的治疗 (2005-2017年).
- 考克斯的比例危险模型分析了与精神疾病相关的死亡风险.
主要成果:
- 分析了10,299名DLBCL患者的队列.
- 诊断后的精神障碍与1年死亡率的增加有关 (aHR=1.51).
- 既有先前存在的 (aHR=1.12) 和诊断后的 (aHR=1.63) 精神障碍都与更糟糕的全因死亡率有关.
结论:
- 精神障碍,特别是诊断后出现的精神障碍,与DLBCL患者的短期和长期死亡率的恶化有关.
- 需要进一步的研究来探索心理健康服务利用率和调解因素.
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