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Updated: Jul 20, 2025

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从PARP1-HPF1复合体中缓慢解离,驱动抑制剂的功效

Petra Stojanovic1, Karolin Luger1,2, Johannes Rudolph1

  • 1Department of Biochemistry, University of Colorado Boulder, Boulder, Colorado 80309, United States.

Biochemistry
|August 2, 2023
PubMed
概括

聚 (ADP-ribose) 聚合酶抑制剂 (PARPi) 当它们与PARP1-HPF1复合体的解离速率缓慢时,其效能会增加. 这一发现指导了下一代PARPi用于癌症治疗的开发.

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